Nuphedragen Review And Information: Does Nuphedragen Work?

Nuphedragen, if you care to believe the advertising material, is the key to weight loss -- thanks to "breakthroughs" in modern science. Spouting impressive terms like "cocaine amphetamine regulatory transcript" (c-a-r-t) and inhibit neuropeptide-y (NPY), it's almost as if the retailers of Nuphedragen are trying to disguise the fact that their product is pretty gosh-darn ordinary.

Because with one exception, all the ingredients in this formula have been used in fat burners since time immemorial -- or darn close to it. And, as you'll see in a moment, the clinical evidence validating their effectiveness is in pretty short supply.

So what's in Nuphedragen?

1) Synephrine: a chemical relative to ephedra derived from citrus aurantium, it was once thought this compound held great promise as a fat burner. Clinical evidence, however, is inconclusive. This study on "The Safety And Efficacy of Citrus Aurantium for Weight Loss" concluded...

"An extensive search of MEDLINE, EMBASE, BIOSIS, and the Cochrane Collaboration Database identified only 1 eligible randomized placebo controlled trial, which followed 20 patients for 6 weeks, demonstrated no statistically significant benefit for weight loss, and provided limited information about the safety of the herb."

This one (Obes Rev. 2006 Feb;7(1):79-88) had this to say...

"While some evidence is promising, we conclude that larger and more rigorous clinical trials are necessary to draw adequate conclusions regarding the safety and efficacy of C. aurantium and synephrine alkaloids for promoting weight loss."

2) Phenylethylamine: an amphetamine-related chemical commonly found in chocolate, and responsible for the famous "chocolate high." You'll find phenylethylamine in many fat burners these days, but for the most part it's a useless addition to any formula.

That's because the vast majority of any phenylethylamine you consume is metabolized by the enzyme monamine oxidase, preventing all but the tiniest amounts from actually reaching the bloodstream.

The only fat burners in which phenylethylamine may have any impact are those that also contain natural monamine oxidase inhibitors (MAOI) to prevent the metabolism of this ingredient. Unfortunately, there aren't any in this formula.

Gaspari's Cytolean (reviewed here) is probably the best of the bunch, as its formula contains 5 natural MAOIs. Nutrex's Lipo 6 X (reviewed here) contains a single MAOI in its formula.

3) Chocamine™: A proprietary extract derived from the cocoa plant. It contains methylxanthines (caffeine and caffeine-like compounds), biogenic amines (defined as "neurotransmitter-related" compounds), as well as amino acids, phyonutrients, minerals, and so on. Although caffeine's ability to work as a fat burner is well established, the effectiveness of other elements of this compound are less so -- especially at this low dose. And I didn't find any clinical studies listed in the PubMed database validating Chocamine™'s positive effects on weight loss (or anything else for that matter).

4) DiCaffeine Malate: The benefits of caffeine for weight loss are well established (see Am J Clin Nutr. 1989 Jan;49(1):44-50, Am J Clin Nutr. 1980 May;33(5):989-97), and therefore it's an important addition to any fat burner. This special "caffeine-bonded-with-malic-acid" is supposed to be more effective, more easily assimilated, and easier on the stomach than "regular" caffeine. However, there is no clinical evidence at this time indicating it offers any fat burning benefits above and beyond those already offered by caffeine.

What's the bottom line on Nuphedragen?

Short of the caffeine, none of the ingredients in this formula have much clinical data validating their usefulness for weight loss. And of course, there have been no clinical studies performed on the Nuphedragen formula itself.

And, at an outrageously priced $60 a bottle (the price is discounted if you make a volume purchase) with no returns on open bottles accepted or any sort of satisfaction guarantee offered, it's a no-brainer. There are simply much better, lower-priced products available on the market for you to bother with Nuphedragen.

Have you used Nuphedragen? Tell me what you think!

Want to learn more about fat burners? Industry professional Will Brink reviews dozens of top weight loss products in his superb "Fat Loss Revealed" Click here to read my review! Click here to visit the Fat Loss Revealed web site!

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