Of course, this new formula adds a few ingredients. Conjugated linoleic acid (CLA) and oleic acid form part of the much-hyped “fast then slow”, “multi-phase” delivery system.
Delivery system aside, CLA has been shown to be helpful for weight loss in several studies (Br J Nutr. 2007 Mar;97(3):550-60, Am J Clin Nutr. 2007 May;85(5):1203-11, J Nutr. 2005 Apr;135(4):778-84), although most studies used dosages over double what is included in this formula.
The crux of this new formula lies with “Synthetic Acacia Rigidula Mimicking Complex”. Acacia rigidula harbors a whole variety of chemical compounds, including mescaline, nicotine, and - of course - phenethylamine (PEA).
Phenethylamine is the “feel good” chemical commonly found in chocolate and is closely related to amphetamine in structure. Both phenethylamine and n-methyl-b-phenylethylamine are included in the complex.
Hordenine is added as well. It’s alleged to be beneficial for fat/weight loss, due to its ability to stimulate the release of norepinephrine, although there is no research to confirm this claim.
However, this ingredient is also included in many formulations that contain the aforementioned phenylethylamine for the reason that it may increase its effectiveness. Ordinarily, phenylethylamine is rapidly metabolized by an enzyme known as “monamine oxidase” – MAO for short. This prevents all but the slightest amounts of phenylethylamine from reaching the bloodstream.
According to the most credible research I’ve seen, hordenine isn’t a MAO inhibitor per se, but a highly selective substrate for a form of MAO known as MAO-B.
What does this mean in plain English?
It means that the enzyme responsible for the breakdown of phenylethylamine is really, really attracted to hordenine, meaning that if the two compounds are both present at the same time, it will prefer to act upon hordenine, allowing the PEA to slip into the bloodstream intact. There it could travel directly to the brain and evoke a “feel good” feeling. That’s the theory anyway. How well it works in the real world is a matter of some speculation.
Tyramine, also normally metabolised by monamine oxidase, may encourage the release of neurotransmitters like dopamine, norepinephrine, epinephrine if the action of monamine oxidase is inhibited by the hordenine included in this formula.
Interestingly, Nutrex advertising material doesn’t emphasize this “feel good” element of the new Lipo 6 X formula too much, instead focusing on the novelty of the “multi-phase delivery system.”
So, is Lipo-6X a significant improvement over the old Lipo-6? Is it worth spending the extra money on?
Well, the CLA is certainly a welcome addition, although Lipo-6X contains less than optimal amounts of the ingredient shown to be effective in most studies.
In my view, the phenethylamine complex is the dark horse in this compilation.
For one, its not sure how effective the hordenine will be at preventing monamine oxidase from metabolizing the phenylethylamine.
And, even if the phenylethylamine is not metabolised, it’s not sure whether an increased level of “feel good” chemicals will actually make this product any more effective for weight loss, as there’s no evidence PEA actually has thermogenic properties.
If you’re a fan of the ephedra-free Lipo-6, all you’re going to be out with this formula is a few extra bucks, since the foundation of the product remains exactly the same (Lipo-6X is available at BodyBuilding.com, one of our recommended online merchants).
|Summary of Nutrex Lipo-6X|