Review Of Gaspari’s CytoLean Fat Burner: Does CytoLean Work?


CytoLean is brought to from Gaspari Nutrition, and it replaces the now discontinued 3° Burn (if you are looking for the newest version of this product, CytoLean V2 is reviewed here!). Rich Gaspari, the CEO of Gaspari Nutrition, is a former pro bodybuilder who’s transformed his love of this very demanding sport into the development of a “much better than average” sports supplement line.

CytoLean, not surprisingly therefore, is not your typical fat burner. Sure, CytoLean does contain surefire favorites like green tea (standardized for catechins and ECGC) and caffeine.

Green tea has shown great promise as a weight loss aid (see the full review of green tea here!), and when used in combination with caffeine has been shown to exhibit even greater fat burning benefits (see Obes Res. 2005 Jul; 13(7): 1195-204).

Cytolean also contains glucoronolactone, a carbohydrate more commonly found in energy drinks like RedBull, RockStar and so on.

However, the crux of the ingredient profile is based upon the ingredient phenylethylamine. In case you don’t remember, phenylethylamine is the “ampthetamine-related” chemical present in chocolate which produces that famous “chocolate high.”

Unfortunately, simple supplementation with phenylethylamine won’t do much to improve your mood.

That’s because the majority of it gets metabolized by an enzyme known as “monamine oxidase.” This prevents all but the slightest amounts from reaching the bloodstream. And alas… no feelings of “well being” or mild euphoria.

That’s where the large majority of the remainder of this formulation’s ingredients come into play — evodia rutaecarpa extract, hordenine, gingko biloba extract, uncaria rhynchophylla, and sinofranchetia chinensis. All of these ingredients are used for their ability to “inhibit” the action of the monamine oxidase enzyme that metabolizes phenylethylamine.

Theoretically therefore, with the action of the monamine oxidase severely compromised, the phenylethylamine could reach the bloodstream unscathed. There, it could travel directly to the brain, and lead to what Gaspari Nutrition calls “a unique “feel good,” euphoric effect that is sure to take the industry by storm.”

Also included in this formula are the amino acids phenylalanine and l-tyrosine. Phenylethylamine (that’s the chocolate “feel good” chemical, right?) can be naturally synthesized from phenylalanine via a process called enzymatic decarboxylation. L-tyrosine is the precursor to several thyroid hormones as well as several important “feel good” neurotransmitters.

Obviously, some real thought went into the development of the Cytolean formula. The $10,000 question is…

Does it work?

The most obvious answer is… there are currently no double-blind, placebo controlled, randomized, peer-reviewed studies that indicate that it does.

On the other hand, this is a very unique and well-thought out product developed by a company known for its quality compilations. Cytolean is a product that has piqued my interest like no other has in a long while. I’ll definitely be giving this product a try, and I’d love to hear from those of you who have tried it yourselves.


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