Well, to begin with there are the usual suspects, caffeine (a mild thermogenic) and green tea.
Green tea, as you know, is a pretty good ingredient for weight loss. In fact, a new study published in the American Journal of Clinical Nutrition (Vol. 81, No. 1, 122-129, January 2005), indicated the ingestion of a tea rich in catechins (catechins are a major component of green tea extract) leads to both a lowering of bodyfat AND of cholesterol levels.
Green tea has also been shown to increase metabolic rate—by about 4% in one study (that’s less than a hundred calories per day for an average individual).
It’s also a powerful anti-oxidant, a glucose moderator and source of the mild thermogenic, caffeine (see the full review of green tea for more clinical references). You can read more about green tea here!
Other ingredients in San Tight!®? Good question…
i. Synephrine: (also known as bitter orange, citrus aurantium) Up until very recently, there was little evidence to show synephrine was much good for anything.
A small body of evidence indicates it may be somewhat useful for weight loss when combined with caffeine and St John’s Wort (see this abstract from PubMed for more). On its own, however, it doesn’t fare so well. Check this extract about Citrus Aurantium from this PubMed abstract…
“An extensive search of MEDLINE, EMBASE, BIOSIS, and the Cochrane Collaboration Database identified only 1 eligible randomized placebo controlled trial, which followed 20 patients for 6 weeks, demonstrated no statistically significant benefit for weight loss, and provided limited information about the safety of the herb.”
ii. Guggulsterones: plant steroids from a resin of a tree native to India. This resin has been used in Ayurvedic medicine for centuries. A study published in The Journal of Associations of Physicians in India in 1989 showed this substance to have a powerful effect in decreasing blood fats (called triglycerides) AND LDL cholesterol (that’s the “bad” cholesterol), while elevating levels levels of the good cholesterol “HDL.”
Additionally, guggulsterones may stimulate the thyroid gland, resulting in a positive effect upon the body’s main thyroid hormones, T3 and T4.
iii. Sclareolide: a compound isolated from clary sage extract. Theoretically, sclareolide is a cAMP stimulator (as is forskohlin). cAMP is what is called a “second messenger.” In other words, this compound is required to “spark” many intracellular processes. This can give rise to various ”total-body” effects as raised thyroid hormone levels and increased fat burning. While there is some evidence that forskohlin exhibits modest weight loss effects, no such evidence exists to validate such a claim for sclareolide.
iv. Yohimbine: The active principal of the bark of the African Yohimbe tree, this compound is often used as a natural aphrodisiac. It is also sold as a drug (in the U.S., a popular brand is Yohimex, which contains 5.4 milligram of yohimbine hydrochloride per tablet) and is used to treat impotency, dilate the pupil of the eye, and stimulate fat loss. Because it can cause unpredictable effects on blood pressure, yohimbine should be approached with caution.
According to the U.S. Food and Drug administration…
Yohimbe is a tree bark containing a variety of pharmacologically active chemicals. It is marketed in a number of products for body building and “enchanced male performance.” Serious adverse effects, including renal failure, seizures and death, have been reported to FDA with products containing yohimbe and are currently under investigation.
The major identified alkaloid in yohimbe is yohimbine, a chemical that causes vasodilation, thereby lowering blood pressure. Yohimbine is also a prescription drug in the United States. Side effects are well recognized and may include central nervous system stimulation that causes anxiety attacks.
At high doses, yohimbine is a monoamine oxidase (MAO) inhibitor. MAO inhibitors can cause serious adverse effects when taken concomitantly with tyramine-containing foods (e.g., liver, cheeses, red wine) or with over-the-counter (OTC) products containing phenylpropanolamine, such as nasal decongestants and diet aids. Individuals taking yohimbe should be warned to rigorously avoid these foods and OTC products because of the increased likelihood of adverse effects.
Yohimbe should also be avoided by individuals with hypotension (low blood pressure), diabetes, and heart, liver or kidney disease. Symptoms of overdosage include weakness and nervous stimulation followed by paralysis, fatigue, stomach disorders, and ultimately death.
v. Vinpocetine: a derivative of an alkaloid derived of a plant from the periwinkle family. In Europe, Japan and Mexico it’s used as a pharmaceutical agent for the treatment of cerebrovascular and cognitive disorders. It may have a slight effect on elevating metabolism, but at this time, that’s mostly speculation.
vi. Bioperine: the patented extract of the black pepper and long pepper berries harvested in India. Bioperine’s value is that it has been established to enhance the bioavailibility of certain supplements through increased absorption. In other words, when combined with Bioperine, numerous vitamins, minerals, amino acids and antioxidants are more efficiently absorbed and utilized in the body.
Bottom line on San Tight? Well…
I’ve always liked green tea and guggulsterones. I’m not sure I’m a big fan of yohimbine when it comes to weight loss, but it may play a role in the overall potency of this product. Synephrine… well, it’s not looking too good for synephrine.
All in all, this is probably a little better product than most. Regardless, remember that not even the best fat burner will do anything for you unless you make the appropriate changes to your diet and lifestyle.
|Summary of San Tight|