MHP’s DREN: Is Drenbuterol Really Legal Clenbuterol?

MHP’s Dren (or Drenbuterol) claims to be a “fat loss breakthrough”, and “an advanced pharmacological approach to fat annihilation!” Of course, this sort of thing is nothing new. Supplement retailers have been making claims like this for years. That said however, Dren does warrant a closer look…

At its core, the Drenbuterol formula is pretty ordinary; it contains several ingredients common to many of the more popular fat burners on the market…

1. 5-HTP (5 Hydroxytryptophan): There is some clinical evidence that 5-HTP is an effective appetite suppressant (see Am J Clin Nutr. 1992 Nov;56(5):863-7), although it’s at a much higher dosage than is included in Dren.

2. Caffeine: Caffeine’s thermogenic properties are well documented (see Am J Clin Nutr. 1989 Jan;49(1):44-50, Am J Clin Nutr. 1980 May;33(5):989-97, Am J Physiol. 1995 Oct;269(4 Pt 1):E671-8). It’s not revealed just how much caffeine is included in the Dren formula, but it’s likely a decent dose, since it’s the first ingredient on the label (ingredients are listed in order of highest dosage to lowest).

3. Yohimbine: A few studies bear out Yohimbe’s positive effect on weight loss (Isr J Med Sci. 1991 Oct;27(10):550-6) but its effects are hardly earth-shattering. If you review the study, you’ll also see individuals were receiving 20 mg of yohimbine per day — and I highly doubt that much is included in the Dren formula.

The one ingredient that makes this formula special is called “beta methoxy phenethylamine.”

Phenethylamine (also called PEA) is the “feel good” amphetamine-like chemical that is found naturally in chocolate. Although there’s no clinical evidence that PEA offers benefits for weight loss, supplement retailers have been using it more frequently in their formulas as a “mood elevator.”

Since PEA is naturally metabolized by an enzyme known as “monamine oxidase” (which ensures only the tiniest amounts of PEA actually enter the bloodstream) the better formulas (like Gaspari’s CytoLean, reviewed here) combine PEA with natural monamine oxidase inhibitors (commonly referred to as MAOIs).

Other products include PEA without MAOIs, and claim that you’ll feel the “euphoria of consuming 1,000 chocolate bars“… a claim without an iota of merit, of course.

OK, now back to beta methoxy phenethylamine. According to MHP, the manufacturers of Dren, this unique form of PEA resists metabolism by monamine oxidase, and acts in much the same manner of ephedrine to encourage the burning of fat. Of course, there is no clinical evidence to indicate this is so — in house or otherwise — so we’re left with nothing but the manufacturer’s word to rely on.

According to Elissa, our resident “in house” scientist…

Beta-PEA is in the same family as both epinephrine and ephedrine. So, IF it can resist breakdown in the body and IF it can cross the blood-brain barrier, then presumably it could also function as a sympathomimetic.

The issue is the modification at the beta-carbon of the “ethylamine” portion of the molecule. There are two carbons (alpha and beta) and an amine here.

Normally, beta-PEA is broken down by an enzyme, monoamine oxidase, which cleaves off the amine terminal group on the ethylamine portion and modifies the alpha carbon. Thus, it should come as no surprise that known, orally-active psychoactive phenethylamines have modifications at the alpha carbon, which would render them resistant to MAO breakdown.

BUT, I don’t see how the methoxy addition to the beta carbon would have a similar impact…looking at what monoamine oxidases do, there doesn’t appear to be any reason why this addition to the beta carbon would matter.

However, judging by the descriptions of Dren’s effects on one popular web site, it is possible this form of PEA retards the breakdown of MAO and does generate some effect.

In case things got a bit technical there, what Elissa is saying is that she can’t see why this unique form of PEA would be any more or less effective surviving MAO metabolism than the form currently found in other popular products, but there is a possibility that this is indeed the case.

Frankly, very little real information is available… certainly not enough to make a statement one way or the other with any degree of certainty.

So does Dren “work” as described?

Well, like Elissa and I have both already said… there’s isn’t any independent study to show it does. At the same time, there may be something to this form of PEA.

“Maybe” is as good as we can get on this one. Before I go though, there is one other thing Elissa shared with me that I’d be remiss to not include here…

PEA derivatives give me the willies, as the substituted phenylethylamines are a very diverse group… and includes agents with an addictive potential (amphetamine, for example).

So I find the lack of supporting studies and health/safety information troubling. In my opinion, supplement companies do not have the right to treat their customers as guinea pigs to test de facto drugs.

You heard her… if you are considering supplementing with Drenbuterol, proceed with caution, and considered yourself forewarned!

If you’ve used Dren, we’d love to hear from you — tell us what you think!

Summary of MHP DREN
 
  • Contains some common, but decent ingredients.
  • Available from various reputable retailers.
 
  • No good info on beta-methoxy-phenethylamine

 

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52 Comments

  1. I am using it for the third time once two boxes and the first of maybe 2.I lost well over 20lbs in a month after a bulking cycle.Yes your heart beats faster and your metablism is higher you get the jitters a little if you are sensitive maybe use 1 pill every other day till your body get used to it or half a day. Overall 4 stars causse it works with side effects kinda like when us run 10 miles the side effets are your sore and loose weight if your looking for a magic pill while you sit on ur butt this isn’t it but it does help if your active and yes it is a medium to heavy stimulant it is what it is i weigh 200 lbs both times taking it and dropped to under 180 quickly u don’t have to take it that long and only 1 time a day its worth the money.

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  2. I have been using Dren for two weeks now with a low carb diet. I am cutting weight for a MMA fight. I have found to be working really quickly. I am amazed with the results because at 35 years old now it is harder to shift the fat from my waist.
    I find it works really well and it doesn’t make you jittery like fat burners that are heavy on Ma Huang. You can take it and it not effect you workday i.e. being scatterbrained and poor attention span.
    I will def’ buy it again for cutting.

    Ian

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  3. I forgot to rate this.
    I read the reviews above and seems like dren doesn’t work for some people or some probably tried the fake ones. For me, i just started taking it and about less than 30 minutes, i felt the euphoric feeling and appetite loss kicked in. I tried other OTC stuff but i didn’t notice any effect from any of them. I think i found the right medicine for me. So far, I’m enjoying the effect of dren. I feel bad for those who didn’t.

    Editor’s comments: There is absolutely no evidence to suggest those who did not experience the same results you did are taking “fake” versions of this product. To our knowledge, there is no issue of this product being faked.

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  4. Use this 5 days – 8:00 in the morning and evening, at 20-00. Also use a high-protein diet and weight training 3 times a week. the 1st day of one hour after the first capsule seemed that there is a burst of energy. at other times absolutely no side effects in the form of frequent pulse, nausea, tremor and dizziness, not even lack of sleep is not – as well go to sleep at 23-00 (3 hours after admission DREN).
    PS: before the use of 14-16 days, the weight was on the spot – 92 kg, BF = 22
    5 days after the start of the reception – 90.5 kg. it’s a placebo effect? Or Dren work is invisibly?

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  5. In the first week or so, there’ll be problems such as feeling like you’re going to vomit, but once you get past that, it’s all downhill from there.

    I’m currently taking it in the form of a 30 day cycle and I lose about a pound a day. But given that my weight fluctuates day to day depending on if I’m at work or not (I seem to only lose weight on the days that I have to go to work). My starting weight was about 198 and currently I’m down to 183.

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  6. I’ve always been a large child and there was nothing I could do to loose the weight. Now that I am an adult I was still having the same difficulties.

    My partner showed me DREN. I’ve used it twice in the past and each time it’s never let me down. It started working in the first week for me. It was a good kick start to any fitness I attempted. It boosted my energy levels, made me alert and clear headed. The typical symptoms that came with DREN appeared but never stayed longer than an hour or two.

    It’s a thermogenic fat burner. Of course you are going to feel hot, nauseous and light headed. Your body is not used to the sudden change in heat and neurotropic state of mind. Eventually it accepts the change and you start to feel better, healthier and happier in general.

    All in all, I ended up loosing a whopping 30 kgs. Partnered with a healthy diet and regular exercise, this will work for you! It certainly did for me! I would rate this product a 10/5 if it was possible.

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  7. I just started taking this and i felt the good side effects and i also felt the nauseous feeling and it went away and came back after my work out which might have been because my lack of sleep the last two days but i havent try other diet pills before but i want to try it to help me lose my last stubborn 36 lbs of fat. I workout everyday added weights and more cardio too so i respode back later if it works for me

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  8. It seem to work for me i notice my stubborn ab area’s of fat are shrinking away after one week of using it and with excerise daily and a low calories diet it works.

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  9. Starting week 2. I sleep fine it just is hard to get started in the am. I feel I actually need 10hrs instead of the 7.5-8hrs of sleep I am getting. I have leaned out considerably in my sides and have noticed I am getting more erections during the course of the day. My mood is more relaxed and chill over all as I generally am all over the place from angry to happy. I usually will take one upon waking with water and have non jitters or nausea. I am eating less. I have lost 4lbs in 2 weeks. I am 5’11” 186lbs

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  10. I bought this a few weeks ago. I am a fitness competitor, train 2 times a day and eat a 100% clean diet. I take this in the mornings before fasted cardio (I empty out half the capsule and only take 1/2 a serving). I feel as though half a serving a pretty strong. I am 5’7 126 pounds about 9% body fat…overall I really like it. I have tried a ton on supplements for fat burning-didn’t want to take the clen way so I think this is helpful in my overall regimen.

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  11. First of all, holy shit! Unbelievable focus and productivity, when I worked out I couldn’t get enough cardio, it smashed my appetite as well, and i didn’t want to eat crappy food. Profuse sweating. I always had trouble focusing in class, but since I’ve been on dren this has been my best semester. To tell you the truth I felt like I was walking on clouds. The only bad was It made me smoke way more cigarettes than usual and NEVER drink coffe, redbull etc. no bueno, I thought I was having a heart attack. Btw I’m a very healthy 27 yo male, other than smoking lol. 6’6 206 lbs

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    • Thanks for sharing your experience, Phil!

      Post a Reply

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