Review: Adapexin-P For Weight Loss

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in Appetite Suppressants, Not Worth the Price, Online Only, Thermogenics

If you believe the advertising, Adapexin-P s the “#1 diet pill of 2012.” Of course, who rated it as such, or why a visitor would view such a rating as credible, is not revealed. It just is, I guess.

The silliness doesn’t stop there, of course. Here’s some other “gems” from the various sales pages I viewed…

“Adapexin contains 8 powerful proven ingredients.”

“You’re getting a diet pill GUARANTEED to be safe and effective.”

“Adapexin-P is a powerful appetite suppressant and weight loss aid that will leave you feeling happy and thin!”

These statements alone would be enough to get the makers of Adapexin-P in trouble with the Federal Trade Commission, but alas, this is just one product in a sea of many making unsubstantiated and outrageous claims.

What’s In Adapexin?

To illustrate just how silly the advertising is, let’s discuss the “clinically proven” ingredients and see how they measure up. Let’s start with the first on the list…

1. Phenylethylamine (PEA): This is the key ingredient in Adapexin-P, present at the “clinically proven” dosage of 37.5 mg. According to the advertising I reviewed, this ingredient, naturally found in chocolate and a chemical cousin of amphetamine, “reduces hunger and suppresses appetite.”

Ooops.

There is absolutely NO evidence phenylethylamine does anything of the sort. That’s correct—there is no clinical evidence that PEA helps with weight loss at all.

There’s another problem; phenylethylamine is rapidly metabolized by the enzyme monamine oxidase (MAO), which means that  taking it orally would do nothing for you since almost none of it would make it into the bloodstream. That’s why most products that contain PEA for mood elevation (like Gaspari’s CytoLean V2 for example) contain natural MAOIs (monamine oxidase inhibitors) to prevent its breakdown.

What about the “clinically proven” dosage of 37.5 mg?

Well, since PEA isn’t clinically proven at all, there is no “effective” dosage. What the makers of Adapexin-P are hoping, apparently, is that you’ll mistake phenylethylamine for the prescription weight loss drug phentermine, which is commonly dispensed in 37.5 mg tablets.

2. Glucomannan: Quite simply, glucomannan is a fiber supplement; it fills you up without adding calories, allowing you to eat less while feeling fuller, faster.

It is a relatively inexpensive supplement, and there’s plenty of clinical data showing it to be effective—both for weight loss and the reduction of blood sugar levels, which is one of the reasons why we recommend it.

But is it a winner in Adapexin-P?

First of all, the advertising indicates the product contains 1,000 mg of glucomannan. It’s not clear whether that means 1,000 mg per serving (which would deliver 2000 mg per day, since the recommended dosage is two capsules twice daily), or 1,000 mg altogether.

If we are to assume the more generous 1,000 mg per serving, this product still falls short of delivering the dosage used in the most promising weight loss study (it used 1,000 mg before all three meals)—which also happens to be the study the retailers reference in their advertising.

So Adapexin does not appear to contain an optimal dose of glucomannan.

Secondly, glucomannan may bind with and hinder the absorption of certain nutrients, and is therefore best used in isolation.

3. Chromax (chromium picolinate): Chromium is a relatively ordinary, standard ingredient in most weight loss supplements, largely because of the role it plays in regulating insulin function.

However, studies validating chromium’s effects are contradictory, and even the most positive ones show only the mildest of effects. This “analysis of randomized trials” on the effectiveness of chromium picolinate for weight loss (see Int J Obes Relat Metab Disord. 2003 Apr;27(4):522-9) concluded…

In conclusion, our meta-analysis suggests a relatively small effect of chromium picolinate compared with placebo for reducing body weight. The clinical relevance of the effect is debatable and the lack of robustness means that the result has to be interpreted with caution.

Contrary to the advertising claims I read for Adapexin-P, there is no evidence that chromium lowers caloric intake by “365 calories per day”, nor does it increase lean muscle mass—something that has also been well-established in clinical studies (see Med Sci Sports Exerc. 1998 Dec;30(12):1730-7, J Sports Med Phys Fitness. 1995 Dec;35(4):273-80).

There is some evidence showing a positive effect on carbohydrate craving and appetite regulation, but this study was performed on individuals with atypical depression (see J Psychiatr Pract. 2005 Sep;11(5):302-14).

4. Raspberry ketones: A phenolic compound derived from red raspberries, raspberry ketones have only really been shown effective in animal studies (you can view the details of the study here). You are not a mouse, and the results of animal studies do not necessarily translate over to humans.

An unpublished pilot study performed on Razberri-K (a patented form of raspberry ketones) demonstrated it enhanced post-exercise fat oxidation, although the results were apparently not large enough to be statistically significant.

Conclusion? Hardly a weight loss winner.

5. Evodiamine: A compound derived from the Chinese fruit Evodia Rutaecarpa. It’s claimed to burn fat by increasing the body’s production of heat, as well as reducing the body’s ability to store fat.

Although a preliminary animal study shows promising results, to date there’s no evidence showing evodiamine works in people.

6. Ginger Root: Ginger contains gingerols, which are chemically related to capsaicin. It does demonstrate some mild thermogenic and metabolism-boosting characteristics, although compliance to a high dosage is likely necessary (obviously therefore, the 50 mg included in this formula is a joke, serving as no more than “label dressing.”)

Some small animal studies performed on zingerone (a component of ginger) have been positive for weight loss (Yakugaku Zasshi. 2008 Aug;128(8):1195-201) albeit the dosage used (170 mg/kg) is too high to be transferred into humans (a 180 lbs. person would need to take about 14 grams a day).

Ginger also seems to accelerate gastric emptying… the opposite of the sort of thing dieters want (Eur J Gastroenterol Hepatol. 2008 May;20(5):436-40).

7. Caffeine: No surprise here; caffeine graces the label of most stimulant based weight loss supplements on the planet. Caffeine’s benefit as a thermogenic is well documented (see Am J Clin Nutr. 1989 Jan;49(1):44-50, Am J Clin Nutr. 1980 May;33(5):989-97), although its effects are relatively mild.

Of course, caffeine also gives most people a much needed “boost” of energy to help them get through their day.

Adapexin-P also contains vitamin B12.

Although supplementing with B-vitamins is often beneficial, it’s unlikely to provide any benefit unless you happen to be deficient… which is unlikely, especially in North America, where the typical diet is rich in animal proteins, milk, cheese, and eggs.

And that’s it… the “weight loss miracle” revealed.

What’s the bottom line on Adapexin-P?

Well, we’re not fans of retailers who make gross fabrications in order to sell their products. And, as you saw as we dissected the formula, there are more ingredients in Adapexin that are NOT clinically proven and included at a less than optimal dosage than those that are. If you wanted to experiment with the most promising core ingredients, you could do so for much less money.

For example, at a reputable retailer like BodyBuilding.com, you can buy…

  • Glucomannan: For less than $10, you can buy a month’s worth of product. Take 2 capsules prior to each meal.
  • Chromium: For about $6, you can buy a 3 month’s supply of a decent chromium supplement.
  • Caffeine: For less than $5, you can buy almost a 2 month’s supply of caffeine (max two tabs per day).

That’s an investment of slightly over $20, and you get all the promising ingredients at appropriate dosages. Why pay $50 when you don’t need to?

But what about all the “review” web sites recommending this product as their top weight loss pick?

These web sites are either affiliates of the retailer (they receive a commission on referred sales), or they are owned and maintained by the retailer themselves, who has created them to appear as an impartial, third party review site to drive sales. This happens all the time.

Does the money-back guarantee offered by the retailer tip the scales in favor of a purchase?

Hardly.

Most retailers who offer such guarantees don’t actually honor them (we have yet to receive such reports about Adapexin-P, however). After all, since many of these products are sold only online by companies which are un-named and virtually untraceable, you don’t have much recourse, should they refuse to do so.

Additionally, the claims made by this retailer are so outrageous (10, 15, and even 20 pounds in 28 days) and their formula so ordinary that we wonder how they could honor such requests and still stay in business.

This is definitely not a product we can recommend.

Summary of Adapexin-P
  • Contains some useful/healthful ingredients: glucomannan, chromium and caffeine.
  • Ingredient amounts listed on label
  • Contains certain ingredients not strongly backed up by evidence
  • Affiliate “review” sites are used to promote the product.

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