Satietrol -- Appetite Suppressant and Weight Loss Aid?

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Satietrol is a appetite suppressing product designed and developed by PacificHealth Laboratories that reportedly decreases hunger, increases satiety (the feeling of "fullness" or satisfaction after a meal) and has lead to sustained periods of weight loss in clinical trials.

And the way Satietrol does this?

By using a milk-derived protein (called "glycomacropeptide") to stimulate the release of an enteric hormone called (are you ready for this?) "cholecystokinin." There is some evidence that this milk-derived protein may indeed be useful for appetite suppression, although I wouldn't call it "earth shattering" by any means (see Physiol Behav. 2008 Jan 28;93(1-2):379-87. Epub 2007 Oct 26)

If Satietrol actually contains enough glycomacropeptide to accomplish the release of cholecystokinin, it's good news indeed -- cholecystokinin is a pretty exciting compound.

OK, OK... what the heck is "cholecystokinin?"

It's a compound that plays an extremely important role in the stomach -- particularly the small intestine. It helps with the digestion of foods by "telling" the pancreas to release digestive enzymes, and the gall bladder to release bile. This helps speed the digestion process along.

Alright, I agree. Not exactly stimulating stuff.

But here's the exciting part...

This compound has consistently demonstrated the ability to decrease hunger significantly. It works on the brain in a very intriguing fashion (scientists are also looking at cholecystokinin as a possible tool to fight panic disorders and depression) to tell it...

"Hey brain! We're full down here, OK? No more, OK?"

According to "in house" clinical trials, Satietrol...

i) Decreased hunger up to 35% for as long as 3.5 hours after eating.

ii) Produced a mean weight loss of 9 lbs in a six-week home trial involving 115 subjects.

iii) Maintained and even enhanced its effect on appetite with continued use.

Of course, these are "in house" studies -- they were not published in any peer-reviewed medical journal as far as I can tell. That does not mean these studies have no credibility -- properly done in-house studies certainly have value. But until the results are verified independently, one must approach the results with a grain of salt. That's only common sense when when the people performing the studies have the most to gain from a positive outcome.

Bottom line on Satietrol?

Here's the tricky thing about this product... it contains more fiber than a 1/4 cup serving of Red River Cereal (a porridge-like breakfast cereal consisting of wheat, flax, and rye grains). I guess what I'm saying is this...

There's enough fiber in this supplement to reduce cravings, eliminate severe swings in blood sugar levels, and if used consistently over the long term -- lead to weight loss. And considering you take this supplement 10-15 minutes before a healthy meal, it's no wonder you eat less, and stay full longer.

Don't get me wrong -- this is a good thing. And Satietrol is pretty cheap -- under $14 for a box of 15. So it's definitely worth experimenting with -- even if you only use it as a fiber supplement/appetite suppresser. But the high fiber content of this product means all the weight loss claims of Satietrol could all be accomplished without the release of any Cholecystokinin at all.

But if Satietrol does effectively stimulate the release of cholecystokinin?

A double bonus. But it's hard to be certain as to its real effects until some independent studies are performed and published in peer-reviewed journals!

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