Naringin - Glossary


A flavonoid glycoside responsible for the bitter taste of grapefruit.  Naringen is metabolized to its aglycone (i.e., sugar-free) form, naringenin, in-vivo.  Both naringin and naringenin are biologically active and can contribute to the “grapefruit juice effect” on ingested drugs.  Unlike grapefruit furanocoumarins, naringin and naringenin have relatively weak effects on “Phase I” drug-metabolizing enzymes; however, naringenin may also affect drug metabolism via esterase inhibition.

Naringin is sometimes added to dietary supplements to enhance the bioavailability of ingested nutrients/nutraceuticals, although specific benefits have not been demonstrated.

In addition to the above, naringin/naringenin have been shown to have antitumor, anxiolytic (anxiety-reducing), anti-inflammatory, antioxidant and anti-osteoporotic effects in cell culture and/or animal experiments.

Chemical name: 4′,5,7-Trihydroxyflavanone-7-rhamnoglucoside

Author: elissa

Elissa is a former research associate with the University of California at Davis, and the author/co-author of over a dozen articles published in scientific journals. Currently a freelance writer and researcher, Elissa brings her multidisciplinary education and training to her writing on nutrition and supplements.

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