A natural plant alkaloid, derived from the Chinese herb Coptis chinensis; also found in Barberry, Goldenseal, Phellodendron and Oregon Grape extracts. In alternative medical systems, berberine is used to control diarrhea and treat infections. Various in-vitro and animal studies have shown it has anti-microbial, anti-tumor, anti-diabetic, anti-inflammatory and cardioprotective effects.
Also known as 4-hydroxy-3-methoxy cinnamic acid. Ferulic acid is a polyphenolic constituent of plant cell walls. It’s abundant in whole grains, fruits and some vegetables. It’s a potent antioxidant in-vitro, although its dietary bioavailability may be limited. Ferulic acid and its derivatives have potential therapeutic applications against diseases such as cancer and diabetes, but human clinical trials are lacking.
Ferulic acid is also used as a “cosmeceutical”, as it can help protect skin against UV-induced damage.
Ferulic acid may also be written as “trans-ferulic acid” as the trans isomer is the dominant natural form.
Also known as aminoacetic acid. Glycine is the smallest amino acid, and is non-essential. Beyond its role as a building block for protein synthesis, glycine functions as an inhibitory neurotransmitter. There is limited evidence that suggests supplemental glycine may improve sleep quality, help stimulate growth hormone release, and treat degenerative diseases such as osteoarthritis.