Guggulsterone (4,17(20)-pregnadien-3,16-dione) is a plant sterol that’s thought to be the active principle in guggul lipid – the resin of the medicinal plant, Commiphora mukul. In Ayurvedic medicine, guggul lipid is used as a treatment for gout, arthritis, inflammation and obesity. Guggul extracts also have potential lipid-lowering and thyroid stimulating effects.
Guggulsterone – either in the form of standardized guggul extracts or “E & Z” guggulsterones* – are often added to fat loss supplements, although the evidence suggests guggul isn’t a weight loss miracle.
See David Tolson’s article, “Guggulsterones Guide” for more information.
*E and Z refer to specific cis/trans isomers