3,5-Diiodo-L-Thyronine - Glossary


Also known as 3,5-T2 or T2.  Like 3,3′-diiodo-l-thyronine, it’s a breakdown metabolite of the active thyroid hormone, T3.  Animal data suggests it can reduce body fat accumulation by reducing oxidative stress and altering hepatic (liver) fat metabolism – without inducing thyrotoxicity.  This is why it’s included in several weight loss supplements, although a) there’s no controlled human data on its use for this purpose; and b) there is little available info on its oral pharmacokinetics (or dose) – the animals in the studies were injected with 3,5-T2, not fed/gavaged.

Author: elissa

Elissa is a former research associate with the University of California at Davis, and the author/co-author of over a dozen articles published in scientific journals. Currently a freelance writer and researcher, Elissa brings her multidisciplinary education and training to her writing on nutrition and supplements.

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