3,5-Diiodo-L-Thyronine
Also known as 3,5-T2 or T2. Like 3,3′-diiodo-l-thyronine, it’s a breakdown metabolite of the active thyroid hormone, T3. Animal data suggests it can reduce body fat accumulation by reducing oxidative stress and altering hepatic (liver) fat metabolism – without inducing thyrotoxicity. This is why it’s included in several weight loss supplements, although a) there’s no controlled human data on its use for this purpose; and b) there is little available info on its oral pharmacokinetics (or dose) – the animals in the studies were injected with 3,5-T2, not fed/gavaged.
