A lignan in sesame seed with a number of interesting physiological effects. Sesamin can enhance plasma Vitamin E status and reduce experimentally-induced inflammation. It can also be converted to the mammalian lignan enterolactone, which is associated with reduced risk of developing certain cancers and heart disease. Sesamin has been touted as a fat loss supplement, on the strength of animal experiments showing it can increase fatty acid oxidation (especially in conjunction with fish oil). There have been no fat loss studies conducted in humans, however, so the benefits are still largely speculative.