Casein Protein Powder Review: Is it the Best Protein? - Bodybuilding Supplements

Casein Protein Powder Review: Is it the Best Protein?

casein protein powder review

Casein protein… it’s worth a look!

What’s the Deal with Casein Protein?

As this casein protein powder review will reveal, casein has achieved a prominent place in the bodybuilding world. I’m sure you’ve already seen terms like “timed-release,” “anti-catabolic” and “micellar” being thrown around in various ads—which certainly make it look like a pretty desirable protein to add to your diet.

What’s it all about?

To begin with, casein supplements may seem pretty cutting edge and high tech, but casein itself is an old friend.

Mammals produce milk to feed their young, and casein is one of the principal proteins in milk. The amount and proportion will vary between animals: casein represents only about 40% of the total protein in human milk, while it’s 80% of the total protein in cow’s milk.

Casein should really be “Caseins”

“Casein” should actually be written “caseins“—as there are 3–4 different, but related types. In cow’s milk, these are called a -, b -, and k -casein. These associate with each other to form comparatively large, complex structures known as “micelles.”

You’d have to be living in a cave to not be familiar with it, at least in food form. Most people eating a Western diet consume some on a daily basis, in the form of milk, cottage cheese, yogurt and hard cheeses, as well as in many prepared foods that include it as an additive.

Highy Nutritious Protein

Casein is a highly nutritious protein, although how it ranks compared to others depends on the scale being used. For example, it has a Biological Value (BV) of 77—lower than the reference protein, egg, which has a BV of 100.

On the other hand, it has a Protein Digestibility Corrected Amino Acid Score (PDCAAS) of 1.0—the same as egg and whey proteins. But whichever way you rank it, casein can help out when it comes to getting high quality protein for building muscle.

Is That All There Is to Casein?


Casein actually has some interesting, and potentially valuable attributes beyond simply being a good source of essential amino acids.

Anti-Catabolic Properties

For one thing, it has anti-catabolic properties—that is, it reduces muscle protein breakdown.

In one study, a 30 g “meal” of casein consumed after an overnight fast reduced whole body protein breakdown by 34% over a 7 hour measurement period. This was in marked contrast to whey protein, which had little effect.


It’s because whey protein is digested very quickly and provides only a short-lived burst of amino acids; whereas, casein forms a sort of “gel” in the stomach that digests very slowly. Consequently, amino acids appear in the blood stream at a lower, but steadier rate.

“Timed Release” Protein

Casein, in effect, functions as a sort of “timed release” protein. This is why many bodybuilders use it as a “bedtime snack”—as it can mitigate the breakdown of muscle protein that occurs during sleep.

Source of Bioactive Peptides

Casein is also a source of bioactive peptides that are released during digestion. Cultures used to produce dairy products such as yogurt, kefir and cheese also produce them. Casein peptides have been identified that can reduce blood pressure, function as carriers for minerals, stimulate the immune system, and inhibit the growth of tumor cells.

So casein may have a variety of health-promoting properties in addition to its nutritional value.

Are there any downsides to casein protein?

Sure: casein is potentially allergenic, although most milk allergies are formed during early childhood.

There is also some controversy over the health effects of genetic variants of b – casein. Specifically, there are two variants that have been identified: A1 and A2. There is some evidence that implicates consumption of milk containing the A1 variant with increased risk of atherosclerosis and type 1 diabetes.

The data is not conclusive, however, as other researchers have either criticized the methods used in these studies, and have not found any direct evidence for atherosclerosis risk in humans.

The issue has yet to be settled.

Keeping Things in Perspective…

I personally don’t worry too much about either issue, however. Despite dark suspicions raised about milk proteins by various health activists, if you have not developed an allergy to milk proteins by the time you’re an adult, you’re highly unlikely to.

In this, casein is no different than other common food allergens. And the increased risk of atherosclerosis from A1-b – casein is still far from proven. In my humble opinion, the benefits of casein for building lean body mass and strength outweigh the limited risks.

Commercial Casein Protein Powders

Supplemental casein is available in several different forms. Commercial casein protein powders use either caseinates or micellar casein.


Caseinates are casein salts. Caseinates are made from casein that’s acidified and precipitated at pH 4.6 (mildly acidic), then treated with alkali, usually in the form of sodium or calcium hydroxide. Micellar casein is produced by ultra- or microfiltration, which preserves the structure of the casein micelles. Which kind should you look for?

Micellar casein

Micellar casein is presumed to be the “gold standard” for supplemental casein protein, but it’s expensive, chalky-tasting and difficult to mix when consumed straight (I know, I’ve tried it). By contrast, caseinates are more soluble, better tasting and easier to handle.

Milk Protein Isolate

Casein is also available in the form of milk protein isolate (MPI) and concentrate (MPC). Since these are isolates made from total milk protein, they are—in effect—casein/whey blends, which have the same proportion of each as is found in the original milk (i.e., 80% casein and 20% whey).

Whey & Casein Combo Might Be Best

There is some evidence that the blend of the two proteins together is superior to each one alone. A comparison study revealed that total milk protein had the “best nutritional quality” and lower rates of deamination/conversion to urea than either micellar casein or whey protein in human volunteers. The researchers suggested that this was due to synergistic effects between the two.

What Casein Protein Powder to Buy…???

There are a huge number of commercial options, ranging from straight casein powders, to milk protein isolates/concentrates, to whey/casein blends. Check out the list at the bottom of the page for some of the options available.

But is it necessary to buy a special powder to get the benefits of casein?

Not at all…you can go straight to the source and buy some plain old milk. Ditto ultrafilitered milk (for the carb-conscious) and cottage cheese. Fermented milk products such as plain yogurt or kefir also offer casein at a reasonable value, with the addition of valuable probiotic bacteria, too.

These are options that will fit most budgets and tastes, so unless you’re already allergic or a vegan, casein is a worthwhile addition to any muscle building diet.

Taste and Consistency

If you are used to whey protein powder, you will find straight casein proteins to be thick and slightly chalky tasting in comparison. My preference for casein protein supplementation is to mix it half and half with whey – not only may this be the most beneficial way to take it (see my point above), but tastes fantastic, and makes a much thicker, more satiating shake than whey.

Common Casein Powders and Casein-Whey Blends

Many well-known brands – like MucleTech, Optimum Nutrition, Muscle Pharm, Now and Allmax Nutrition – sell casein proteins or whey-casein blends. You really can`t go wrong with any of them. Pick your favorite, and reap the benefits of protein powder!

Casein proteins are available at!

Casein Protein Powder Review Conclusion

Casein protein is a superlative quality protein that is well worth experimenting with – although you do not need to purchase a bulk powder to do so, since it is present in commonly consumed foods like milk, cottage cheese, and yogurt.

Having said that, if you use a protein powder regularly, you might want to consider adding casein into the mix.

It’s damn good stuff.

Author: elissa

Elissa is a former research associate with the University of California at Davis, and the author/co-author of over a dozen articles published in scientific journals. Currently a freelance writer and researcher, Elissa brings her multidisciplinary education and training to her writing on nutrition and supplements.

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