Glycocyamine
An intermediate in creatine synthesis. It’s included in certain creatine transport supplements as it represents an additional pathway for increasing creatine storage in muscle tissue. It also has hypoglycemic effects, and may be able to enhance creatine uptake in muscle without a sugar-mediated insulin spike. Glycocyamine is a questionable addition as it can also increase homocysteine (a risk factor for cardiovascular...
Bioperine®
A proprietary black pepper extract standardized for piperine (95%), manufactured by Sabinsa Corporation.
Piperine
The compound responsible for the pungency of black pepper. Piperine may have anti-depressant and anti-tumor effects, although the primary reason for its use in supplements is different…Piperine can enhance the intestinal absorption of a number of different compounds and drugs; as well as inhibit drug-metabolizing enzymes in the liver – as a consequence, piperine can enhance the bioavailability of drugs and nutraceutical...
-(-)3,4-Divanillyltetrahydrofuran
A bioactive compound in “Stinging Nettle” (Urtica dioica) used in certain bodybuilding/testosterone-boosting supplements. In-vitro research has shown it can bind tightly to sex hormone binding globulin (SHBG), so theoretically, it has the potential to increase bioavailable (free) testosterone. There are no human—or even animal—studies, however, so at this point, the ability of oral -(-)3, 4-Divanillyltetrahydrofuran to...
Stinging Nettle
See Urtica dioica.
Urtica dioica
Also known as Stinging Nettle. Urtica dioica has been used as a folk medicine for centuries. Stinging nettle extracts are also used as an alternative therapy for benign prostatic hyperplasia (BPH, or enlarged prostate). Cell culture experiments have shown that Urtica extracts can inhibit the binding activity of SHBG (sex hormone binding globulin). SHBG binds to testosterone, and high levels limit the amount of free testosterone able...
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