{"id":552,"date":"2008-12-11T22:11:21","date_gmt":"2008-12-11T20:11:21","guid":{"rendered":"http:\/\/blog.ultimatefatburner.com\/?p=552"},"modified":"2015-02-12T21:13:57","modified_gmt":"2015-02-13T02:13:57","slug":"pathetic","status":"publish","type":"post","link":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/pathetic\/","title":{"rendered":"This is Pathetic…"},"content":{"rendered":"

I’m currently writing a review of LG Sciences pSARM.\u00a0 Evidently, the company is\u00a0doing\u00a0its best to convince would-be customers that the primary ingredient, osthol, binds to androgen receptors.\u00a0 So one of their reps\u00a0posted a drawing superimposing osthole over testosterone<\/a>\u00a0on a bbing board to\u00a0“prove” it “fits” androgen receptors.*<\/p>\n

There’s just (ahem!) a few problems with this argument…<\/p>\n

1. Ligands – and their binding sites – are THREE-DIMENSIONAL<\/a> – not two.\u00a0\u00a0What LG Sciences has done\u00a0is a bit like looking up at the night sky at a constellation, and assuming all the stars in a particular formation lie in the same plane, simply because that’s what it looks like from Earth.\u00a0 2-D chemical formulas are simply a shorthand way of representing molecules, but like a painting or photograph, have no depth. Seemingly mall differences in structure can add up to large differences in shape – where it matters. And despite the alleged similarity, there are some pretty significant differences between the two.<\/p>\n

2. If 2-D structural similarity is all that matters, there are plenty of other\u00a0compounds that are a much\u00a0closer match for testosterone\u00a0than osthol is. Like estradiol (estrogen), for example. \ud83d\ude00<\/p>\n

3. If 2-D structural similarity is all that matters, then perhaps the\u00a0brain trust\u00a0at LG Sciences would care to explain why many of the SARM drugs currently being researched<\/a> have even less structural overlap w\/testosterone than osthol does.<\/p>\n

In short,\u00a0it’s just marketing, and a rather\u00a0weak attempt at\u00a0that.\u00a0\u00a0You “prove” androgen receptor binding capacity by – surprise!!! – conducting receptor binding studies<\/a>\u00a0(scroll down to “In Vitro and In Vivo Models for Evaluation of AR Ligands”)\u00a0You\u00a0“prove”\u00a0a compound acts like a SARM by demonstrating it has tissue-selective effects<\/a>.\u00a0<\/p>\n

If you’re going to play “scientist,” then you need to play by the “rules.”\u00a0 It’s that simple.<\/p>\n

Pathetic.<\/p>\n

*This drawing is referred to in the pSARM write up on their web site, but does not actually appear there. Maybe they finally realized just how thick it made them look.<\/p>\n","protected":false},"excerpt":{"rendered":"

I’m currently writing a review of LG Sciences pSARM.\u00a0 Evidently, the company is\u00a0doing\u00a0its best to convince would-be customers that the primary ingredient, osthol, binds to androgen receptors.\u00a0 So […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3,27,28],"tags":[135,248,1012,1234,1348,1432,1622],"_links":{"self":[{"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/posts\/552"}],"collection":[{"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/comments?post=552"}],"version-history":[{"count":3,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/posts\/552\/revisions"}],"predecessor-version":[{"id":8234,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/posts\/552\/revisions\/8234"}],"wp:attachment":[{"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/media?parent=552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/categories?post=552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/tags?post=552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}