According to researchers at UC Irvine, dietary oleic acid (the main fatty acid in olive oil and avocados) triggers the production of a hormone, oleoylethanolamide, that helps regulate body weight and appetite.<\/p>\n
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Fatty foods may not be the healthiest diet choice, but those rich in unsaturated fats \u2013 such as avocados, nuts and olive oil \u2013 have been found to play a pivotal role in sending this important message to your brain: stop eating, you\u2019re full.<\/em><\/p>\n
A new study by UC Irvine pharmacologists shows that these fats trigger production of a compound in the small intestine that curbs hunger pangs. This discovery, the researchers say, points toward new approaches to treating obesity and other eating disorders.<\/em><\/p>\n
Daniele Piomelli, the Louise Turner Arnold Chair in Neurosciences, and his colleagues have studied how a fat-derived compound called oleoylethanolamide regulates hunger and body weight. In their current work, which appears in the Oct. 8 issue of Cell Metabolism, they found that an unsaturated fatty acid called oleic acid stimulates production of OEA, which in turn decreases appetite.<\/em><\/p>\n
Oleic acid is transformed into OEA by cells in the upper region of the small intestine. OEA then finds its way to nerve endings that carry the hunger-curbing message to the brain. There, it activates a brain circuit that increases feelings of fullness. In previous studies, Piomelli found that increasing OEA levels can reduce appetite, produce weight loss and lower blood cholesterol and triglyceride levels.<\/em><\/p>\n
Piomelli believes OEA could be used in a variety of drugs because it is a key to the way the body naturally handles fatty foods and regulates eating and body weight.<\/em><\/p>\n
\u201cWe are excited to find that OEA activates cell receptors that already have been the focus of successful drug development,\u201d he said. \u201cThis gives us hope for a new class of anti-obesity drugs based on the savvy use of natural appetite-controlling mechanisms.\u201d<\/em><\/p><\/blockquote>\n
This\u00a0could help explain some of the success of the Mediterranean diet and other moderate fat\/carb-restricted diets, vs. conventional low fat diets.\u00a0 It will be interesting to see how this line of research develops.<\/p>\n","protected":false},"excerpt":{"rendered":"
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