{"id":187,"date":"2008-06-30T00:39:11","date_gmt":"2008-06-29T22:39:11","guid":{"rendered":"http:\/\/blog.ultimatefatburner.com\/wordpress\/oleoyl-estrone\/"},"modified":"2015-02-12T21:06:27","modified_gmt":"2015-02-13T02:06:27","slug":"oleoyl-estrone","status":"publish","type":"post","link":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/oleoyl-estrone\/","title":{"rendered":"Oleoyl-Estrone"},"content":{"rendered":"

Admittedly, I don’t keep a very close watch on what Big Pharma is up to, when it comes to the development of anti-obesity drugs…let’s face it, most of ’em don’t do much, and carry a significant risk of side effects.\u00a0 Some of the sides are relatively harmless (i.e., anal leakage from Orlistat<\/a>), while others are more serious (i.e., depression\/suicide risk from Rimonabant<\/a>).\u00a0 And – to be blunt – I feel that both healthy weight loss and long-term weight maintenance are best achieved through significant lifestyle changes…which have added benefits for health, fitness and longevity.<\/p>\n

Nonetheless, a pretty interesting “natural” drug is in the pipeline, that bears close watching: oleoyl-estrone.\u00a0<\/p>\n

What the heck is it?\u00a0 Oleoyl-estrone is a naturally-occurring hormone produced by adipose tissue, that helps communicate levels of body fat to the brain.\u00a0 It’s a fatty acid ester of the estrogen hormone estrone<\/a>, which – paradoxically – does not appear to have estrogenic effects<\/a> when administered orally – at least in rodent studies.\u00a0 Oleoyl-estrone causes reductions in food intake and body fat, without a loss of body protein<\/a>.\u00a0 It appears to be safe, and was used successfully in one case study on a morbidly obese man<\/a> who lost 38.5\u00a0kg (almost 85 pounds)\u00a0over 27 months of intermittent treatment with no dietary restriction.\u00a0 Larger human clinical trials<\/a> are currently being conducted.<\/p>\n

Of course, rats aren’t people, and the one obese guy this was used on, was still obese at the end of the trial.\u00a0 So while it looks promising, I’d hesitate to call it a miracle treatment.\u00a0 Still, it’s worth keeping an eye on…which I plan on doing.<\/p>\n","protected":false},"excerpt":{"rendered":"

Admittedly, I don’t keep a very close watch on what Big Pharma is up to, when it comes to the development of anti-obesity drugs…let’s face it, most of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[28],"tags":[],"_links":{"self":[{"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/posts\/187"}],"collection":[{"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/comments?post=187"}],"version-history":[{"count":4,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/posts\/187\/revisions"}],"predecessor-version":[{"id":8089,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/posts\/187\/revisions\/8089"}],"wp:attachment":[{"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/media?parent=187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/categories?post=187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/ufb-blog\/wp-json\/wp\/v2\/tags?post=187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}