{"id":763,"date":"2013-01-13T20:57:29","date_gmt":"2013-01-13T20:57:29","guid":{"rendered":"http:\/\/bodybuilding.ultimatefatburner.com\/?p=763"},"modified":"2015-03-09T09:27:09","modified_gmt":"2015-03-09T13:27:09","slug":"u4ea","status":"publish","type":"post","link":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/u4ea.html","title":{"rendered":"Review: Pure Life U4EA"},"content":{"rendered":"<p>&#8220;<em>You Get Mood Enhancement, Stress Relief, and Increased Endurance\u2014All in one product! Best of all U4EA is Safe &amp; Healthy! U4EA contains only safe ingredients that work\u2014quickly! Most users report feeling the effects in as little as 15\u201320 minutes.<\/em>&#8221;<\/p>\n<p>There&#8217;s another term for compounds that exert cognitive effects: &#8220;nootropics&#8221;. Otherwise known as &#8220;smart drugs&#8221;, they can help you feel a little sharper for that exam, or keep you focused while pushing out those last few reps.<\/p>\n<p>Nootropic agents are pretty popular with bodybuilders, which is why they&#8217;re included in so many different supplement blends, from pre-workout stimulants to fat burners. They&#8217;re also sold as standalone products, although mostly as individual ingredients\u2014which are then used to create customized stacks.<\/p>\n<p>Experimenting with different compounds and combinations can be a pain, however&#8230;Thus, it&#8217;s nice to see some nootropic formulas coming onto the market. Ideally, these take the guesswork (not to mention the hassle of capping bulk powders) out of the equation.<\/p>\n<p>Pure Life U4EA is one of those formulas. It comes in two, somewhat different versions, depending on whether you buy it in capped or in bulk powder form.<\/p>\n<blockquote>\n<table width=\"100%\" border=\"0\" cellspacing=\"2\" cellpadding=\"2\" class=\"noBorder\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"50%\" height=\"117\"><strong>Serving Size:<\/strong><strong> 4 <\/strong><strong>Capsules<\/strong><br \/>\n<strong>Unique Proprietary Matrix 1820mg <\/strong><br \/>\nPhenibut<br \/>\nL-Theanine<br \/>\nL-Tyrosine<br \/>\nL-Glycine<br \/>\nTaurine<br \/>\nSceletium Tortuosum<br \/>\nBioperine\u00ae<\/td>\n<td valign=\"top\" width=\"50%\"><strong>Serving Size: 1 Teaspoon (tsp) <\/strong><br \/>\n<strong>Unique Neurotrophic Matrix 4000mg <\/strong><br \/>\n2-Aminoethanesulfonic Acid<br \/>\n4-Amino-3-Phenylbutyric Acid HCL<br \/>\n2-Amino Acetic Acid<br \/>\nGamma-Glutamylethylamide<br \/>\nOxitriptan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n<p>Of course, the way the powder ingredients are written, the two look more than &#8220;somewhat different.&#8221; But this is only because they&#8217;re written in &#8220;chemicalese&#8221;\u2014the ingredients in the powder are actually taurine, phenibut, glycine, theanine and 5-HTP. So the two forms share a number of common components, although it&#8217;s likely that the amounts\/proportions differ.<\/p>\n<p>So what are these ingredients, and what do they have to offer?<\/p>\n<p><strong>Phenibut\/4-Amino-3-Phenylbutyric Acid HCL:<\/strong> This is a derivative of GABA\u2014an inhibitory neurotransmitter that&#8217;s sold as a supplement in its own right. GABA has mild sedative effects that can aid in relaxation and sleep. Phenibut allegedly crosses the blood-brain barrier more efficiently than GABA does, and many consider it superior. This assessment is largely anecdotal, however. Although it&#8217;s <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11830761\" target=\"_blank\" rel=\"noopener\">used in Russia as an anxiolytic (anxiety-reducing) and nootropic drug<\/a>, most of the research on phenibut is published in obscure, Russian-language journals, and has not been subjected to the kind of critical evaluation typical of Western science.<\/p>\n<p>It&#8217;s fairly popular stuff, though, so it&#8217;s reasonable to assume that it works. A common user complaint, however, is that tolerance to phenibut&#8217;s effects occurs quickly, so only sporadic use is advised.<\/p>\n<p><strong>L-Theanine\/Gamma-Glutamylethylamide:<\/strong> A non-protein amino acid found in tea, l-theanine has <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15378679\" target=\"_blank\" rel=\"noopener\">relaxant<\/a> and <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/25\/12\/25_12_1513\/_pdf\" target=\"_blank\" rel=\"noopener\">neuroprotective<\/a> effects. It&#8217;s often added to fat loss supplements, primarily for its effects on mood\/cognition (both <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18841456\" target=\"_blank\" rel=\"noopener\">alone<\/a> and <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18641209\" target=\"_blank\" rel=\"noopener\">synergistically with caffeine<\/a>).<\/p>\n<p><strong>L-Tyrosine:<\/strong> <a href=\"https:\/\/www.ultimatefatburner.com\/l-tyrosine.html\">L-Tyrosine<\/a> is a non-essential amino acid synthesized from phenylalanine. It&#8217;s the precursor to several important physiological compounds, including thyroid hormone(s) and the catecholamine neurotransmitters (dopamine, norepinephrine and epinephrine). Tyrosine administration has been shown to improve mood and performance under <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17585971?ordinalpos=11&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">environmental<\/a> and <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1599383?ordinalpos=4&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">physical stress<\/a>.<\/p>\n<p><strong>L-Glycine\/2-Amino Acetic Acid:<\/strong> The non-essential amino acid glycine has a variety of physiological functions, including functioning\u2014as GABA does\u2014<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11396606\" target=\"_blank\" rel=\"noopener\">as an inhibitory neurotransmitter<\/a>. Supplemental glycine may <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1479-8425.2007.00262.x\/abstract\" target=\"_blank\" rel=\"noopener\">improve sleep quality<\/a> and <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/622050\" target=\"_blank\" rel=\"noopener\">increase growth hormone levels<\/a>.<\/p>\n<p><strong>Taurine\/2-Aminoethanesulfonic Acid:<\/strong> <a href=\"https:\/\/www.ultimatefatburner.com\/bodybuilding\/taurine-review.html\">Taurine<\/a> a sulfur-containing amino acid. It was originally isolated from ox bile, hence the name (the scientific name for the ox is <em>Bos taurus<\/em>).<\/p>\n<p>Probably the best-known use of taurine is in &#8220;Red Bull&#8221; energy drinks, where it&#8217;s combined with caffeine and glucuronolactone. Red Bull itself has been studied, and reports confirm that it&#8217;s effective for <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11665810?ordinalpos=26&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">enhancing mental and physical performance<\/a>, but there is little information on what\u2014if any\u2014role taurine plays in producing these effects.<\/p>\n<p>High dose experiments with rats and mice have shown that taurine can influence mood\/behavior by <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15240184?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1\" target=\"_blank\" rel=\"noopener\">acting as an anxiolytic<\/a>. Currently, clinical trials in humans for <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00391001?term=NCT00391001&amp;rank=1\" target=\"_blank\" rel=\"noopener\">controlling manic symptoms<\/a> in <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00217165?\" target=\"_blank\" rel=\"noopener\">subjects with bipolar disorder<\/a> are currently being conducted, but there is little data available yet.<\/p>\n<p><strong>Sceletium tortuosum: <\/strong>Popularly known as &#8220;kanna&#8221;, Sceletium tortuosum is a medicinal plant used in South Africa for its mood-enhancing, stress-reducing effects. Certain psychoactive alkaloids have been identified (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18280080\" target=\"_blank\" rel=\"noopener\">mesembrine, mesembrenone and mesembrenol<\/a>), but it does not appear to have been studied very thoroughly. One of the alkaloids, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18775771\" target=\"_blank\" rel=\"noopener\">mesembrine, may act as a serotonin reuptake inhibitor<\/a>, which\u2014if verified\u2014would make it a natural antidepressant.<\/p>\n<p><strong>Oxitriptan (5-HTP): <\/strong>5-HTP is a metabolite of the essential amino acid <a href=\"https:\/\/www.ultimatefatburner.com\/glossary\/ltryptophan\/\">l-tryptophan<\/a> and an intermediate in the production of the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) as well as the hormone melatonin. 5-HTP is used as an alternative treatment for <a href=\"http:\/\/www.anth.ucsb.edu\/faculty\/blackwell\/Documents\/5-HTP.Pharm.Therap.pdf\" target=\"_blank\" rel=\"noopener\">depression<\/a>, and included in a number of supplements to improve mood and assist with <a href=\"http:\/\/ajcn.nutrition.org\/content\/56\/5\/863.full.pdf+html\" target=\"_blank\" rel=\"noopener\">appetite control\/weight loss<\/a>.<\/p>\n<p>Overall, U4EA contains some obviously active compounds. I thought it looked pretty interesting, which is why I ordered a bottle from Bodybuilding.com to try for myself. The reviews looked promising and I was curious.<\/p>\n<p>How did it go? Well, let&#8217;s just say that &#8220;interesting&#8221; is a good description. So is &#8220;unpredictable.&#8221; Truth is, my results were uneven.<\/p>\n<p>First time I tried it, I took the recommended dose of 4 caps. I could actually feel it kick in&#8230;it was a reasonably pleasant sensation, but it didn&#8217;t seem to last long.<\/p>\n<p>Next, I decided to test it as a pre-workout supp. Since 4 caps was a little underwhelming, I upped it to 5.<\/p>\n<p>Wow. By the time I got to the gym, I was looped. I ambled into the locker room feeling vacantly happy and grinning ear-to-ear like a loon. Loved it&#8230;reminded me of my college daze. \ud83d\ude09<\/p>\n<p>But once again\u2014it didn&#8217;t last. The buzz disappeared within minutes of hitting the weights. And while my workout was decent, there was nothing special about it. There was no increased performance, focus or endurance.<\/p>\n<p>Nonetheless, I figured it would be nice to recapture that happy buzz, so a few days later, I downed another 5 caps. I was at my computer, working on a blog post when it hit&#8230;only this time, it was in the opposite direction. It was all I could do to keep from face-planting on the keyboard, so I finally gave up trying to work, and crawled into bed for an extended nap\u2014something I almost never do. Admittedly, I was fighting a cold and was short on sleep, but that definitely wasn&#8217;t the reaction I expected. Even worse, I woke up feeling distinctly hungover\u2014ugh.<\/p>\n<p>After that, I decided to experiment with smaller doses. Taking it during the day didn&#8217;t do jack for me, but I found that 2\u20133 caps before bedtime seemed to facilitate sleep. While I don&#8217;t generally suffer from insomnia, I do end up tossing and turning every once in a while. This strikes me as a pretty good reason to hold on to the rest of the caps.<\/p>\n<p>As you can guess from the above, I&#8217;m &#8220;iffy&#8221; on U4EA. Of the claims made on the bottle, &#8220;Fast Acting&#8221; and &#8220;Promotes Positive Feelings&#8221; are the only ones I can vouch for. On the flip side, &#8220;Increased Focus and Performance&#8221; and &#8220;Improved Athletic Recovery&#8221; are problematic: I certainly experienced neither. For what it&#8217;s worth, however, user feedback is pretty positive\u2014especially for those who are coping with higher-than-normal stress\/anxiety. So it could be that I&#8217;m just not stressed out enough to really notice a difference, at least with doses under 4 caps.<\/p>\n<p>All things considered, U4EA definitely &#8220;works&#8221;\u2014if you take the right amount, you&#8217;ll feel it. Based on my experience, however, what you feel may\u2014or may not\u2014&#8221;work&#8221; for you&#8230;depends on the dose and context. Nonetheless, it&#8217;s a product that could be worth experimenting with, especially if you&#8217;re under a lot of stress, or could use a little help getting a good night&#8217;s sleep.<\/p>\n<table cellspacing=\"0\">\n<tbody>\n<tr>\n<td class=\"rating\" colspan=\"2\">Summary of Pure Life U4EA<\/td>\n<\/tr>\n<tr>\n<td class=\"thumbUp\"><\/td>\n<td>\n<ul class=\"pro\">\n<li>Some research support for ingredients.<\/li>\n<li>Seems to work, although my results were unpredictable.<\/li>\n<li>Fast acting.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"thumbDown\"><\/td>\n<td>\n<ul class=\"con\">\n<li>My results were uneven.<\/li>\n<li>Initial effects did not last long.<\/li>\n<li>Did not improve my workout focus or concentration.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;You Get Mood Enhancement, Stress Relief, and Increased Endurance\u2014All in one product! Best of all U4EA is Safe &amp; Healthy! U4EA contains only safe ingredients that work\u2014quickly! Most [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[14],"tags":[158],"_links":{"self":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/763"}],"collection":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/comments?post=763"}],"version-history":[{"count":4,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/763\/revisions"}],"predecessor-version":[{"id":2610,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/763\/revisions\/2610"}],"wp:attachment":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/media?parent=763"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/categories?post=763"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/tags?post=763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}