{"id":323,"date":"2009-07-20T23:54:15","date_gmt":"2009-07-20T23:54:15","guid":{"rendered":"http:\/\/bodybuilding.ultimatefatburner.com\/?p=323"},"modified":"2015-02-12T15:33:47","modified_gmt":"2015-02-12T20:33:47","slug":"flameout","status":"publish","type":"post","link":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/flameout.html","title":{"rendered":"Review: Biotest Flameout Fish Oil Supplement"},"content":{"rendered":"<p>&#8220;<em>So, do you want to end inflammation and give yourself the best health insurance policy available, all while changing your body composition for the better?<\/em><\/p>\n<p><em>There&#8217;s no doubt about it, Flameout\u2122 is the most potent anti-inflammatory fatty-acid blend ever produced, and it&#8217;s formulated especially for men.<\/em>&#8221;<\/p>\n<p>Biotest Flameout is a pretty simple supplement. It&#8217;s a <a href=\"https:\/\/www.ultimatefatburner.com\/vitamins\/fish-oil-review.html\">fish oil<\/a> product that supplies DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid)\u2014along with some CLA (conjugated linoleic acid).<\/p>\n<blockquote><p>Calories 52<br \/>\nCalories from Fat 52<br \/>\nTotal Fat 5.6g<br \/>\nSaturated Fat 40mg<br \/>\nCholesterol 0mg<br \/>\nTotal Carbohydrate 0g<br \/>\nProtein 1.2g<br \/>\nTotal free-fatty acids 4,625mg<br \/>\nDHA 2,200mg<br \/>\nEPA 880mg<br \/>\nCLA t10,c12 212mg<br \/>\nCLA c9,t11 140mg<\/p><\/blockquote>\n<p>Flameout isn&#8217;t just any old fish oil supplement, however. Unlike most other commercial offerings, it&#8217;s a) highly concentrated; and b) contains considerably more DHA than EPA.<\/p>\n<p>Why does that matter?<\/p>\n<p>There&#8217;s an obvious advantage to consuming a fish oil concentrate: you can take less of it. A 5.6g serving of Flameout contains more than 3g of combined DHA + EPA. It would take 10g of a standard, 30% EPA\/DHA product to consume the same amount&#8230; and even then, the ratio of DHA to EPA would be much lower. If you wanted to duplicate the amount of DHA in 4 caps of Flameout, it would take ~18g\u201319g of fish oil to do it.<\/p>\n<p>So Flameout is certainly convenient&#8230; But are there any benefits to consuming more DHA than EPA? Are there other reasons to prefer Flameout to more conventional fish oil supps?<\/p>\n<p>Well, there just might be&#8230;<\/p>\n<p><a href=\"http:\/\/medind.nic.in\/icb\/t05\/i3\/icbt05i3p239.pdf\" target=\"_blank\" rel=\"noopener\">DHA is an extremely important metabolite<\/a>: it comprises 40% of the polyunsaturated fatty acids (PUFAs) in the brain and 60% in the retina.<\/p>\n<p>It also accounts for 50% of the weight of neuronal membranes. This is why <a href=\"http:\/\/umm.edu\/health\/medical\/altmed\/supplement\/docosahexaenoic-acid-dha\" target=\"_blank\" rel=\"noopener\">it&#8217;s critical for proper neurological development in infancy<\/a>.<\/p>\n<p>And\u2014although it&#8217;s often lumped together with EPA in fish oil studies\u2014the two aren&#8217;t interchangeable.<\/p>\n<p>For example, DHA is the precursor for <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2696125\/?tool=pubmed\" target=\"_blank\" rel=\"noopener\">neuroprotective, anti-inflammatory docosanoids<\/a>. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19158225\" target=\"_blank\" rel=\"noopener\">DHA supplementation also significantly reduces markers of systemic inflammation<\/a>. In addition, <a href=\"http:\/\/www.ars.usda.gov\/research\/publications\/publications.htm?SEQ_NO_115=206438\" target=\"_blank\" rel=\"noopener\">it may be more effective than EPA for improving insulin sensitivity<\/a>. In sum, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8741170\" target=\"_blank\" rel=\"noopener\">DHA is responsible for many of the cardioprotective effects observed with fish oil administration<\/a>.<\/p>\n<p>Now, EPA and DHA <strong>are<\/strong> interconvertable to some extent: <a href=\"http:\/\/jn.nutrition.org\/content\/138\/1\/30.full\" target=\"_blank\" rel=\"noopener\">supplementation with DHA also increases blood levels of EPA<\/a>. It doesn&#8217;t work quite so well from the other direction, however\u2014<a href=\"http:\/\/ajcn.nutrition.org\/content\/66\/3\/649.full.pdf+html\" target=\"_blank\" rel=\"noopener\">particularly in men<\/a>.<\/p>\n<p>Incidentally, this is why fish oil is a better source of omega-3 fatty acids than flax oil: studies on supplementation with alpha-linolenic acid (the omega-3 fatty acid in flaxseed), show that both women and <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12323085\" target=\"_blank\" rel=\"noopener\">men can convert it to EPA<\/a>, but only <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12323090\" target=\"_blank\" rel=\"noopener\">women can produce measurable amounts of DHA<\/a>. This gender-based difficulty in converting EPA to DHA provides some support for Biotest&#8217;s contention that EPA-rich fish oil supplements are sub-optimal for men.<\/p>\n<p>Admittedly, &#8220;some support&#8221; falls short of &#8220;proof&#8221;: there&#8217;s plenty of evidence that regular ol&#8217; fish oil consumption is beneficial for men&#8230; a standard fish oil product still provides plenty of DHA, after all.<\/p>\n<p>Nonetheless, there appear to be differences in how humans respond to <a href=\"http:\/\/ajcn.nutrition.org\/content\/79\/4\/674.full\" target=\"_blank\" rel=\"noopener\">EPA-rich<\/a> vs. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16697494\" target=\"_blank\" rel=\"noopener\">DHA-rich fish oils<\/a>. If\u2014as some researchers suggest\u2014<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19540099\" target=\"_blank\" rel=\"noopener\">DHA and AA (arachidonic acid) alone are the true essential fatty acids<\/a>, then consuming a DHA-rich product like Flameout might be preferable.<\/p>\n<p>A serving of Flameout also contains 353mg CLA isomers. Although it&#8217;s best known as a fat loss supp, CLA is also <a href=\"http:\/\/www.jlr.org\/content\/46\/10\/2134.full\" target=\"_blank\" rel=\"noopener\">a COX-2 (cyclooxygenase-2) inhibitor<\/a>\u2014at least in mice. Since COX-2 is responsible for the production of pro-inflammatory prostaglandins, CLA could provide additional protection against inflammation&#8230;in theory.<\/p>\n<p>Unfortunately, human studies using much larger amounts of CLA have shown either <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17313718\" target=\"_blank\" rel=\"noopener\">no reduction in markers of inflammation<\/a>, or\u2014paradoxically\u2014<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18641189\" target=\"_blank\" rel=\"noopener\">increases<\/a>. Thus, I doubt this ingredient offers any real benefit&#8230; particularly in the (very small) amount provided.<\/p>\n<p>But this is a minor quibble&#8230; overall, I like the look of Flameout. It&#8217;s an interesting, high quality and competitively-priced alternative to regular fish oil and fish oil concentrates. As I see it, it&#8217;s a potentially worthwhile supplement for both men and women looking to optimize their intakes of essential fatty acids.<\/p>\n<table cellspacing=\"0\">\n<tbody>\n<tr>\n<td class=\"rating\" colspan=\"2\">Summary of Biotest Flameout<\/td>\n<\/tr>\n<tr>\n<td class=\"thumbUp\"><\/td>\n<td>\n<ul class=\"pro\" style=\"height: 90px\">\n<li>Excellent source of DHA.<\/li>\n<li>More convenient than regular fish oil caps.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"thumbDown\"><\/td>\n<td>\n<ul class=\"con\" style=\"height: 90px\">\n<li>CLA component is underdosed.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;So, do you want to end inflammation and give yourself the best health insurance policy available, all while changing your body composition for the better? There&#8217;s no doubt [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[62],"tags":[64,63],"_links":{"self":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/323"}],"collection":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/comments?post=323"}],"version-history":[{"count":4,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/323\/revisions"}],"predecessor-version":[{"id":2396,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/323\/revisions\/2396"}],"wp:attachment":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/media?parent=323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/categories?post=323"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/tags?post=323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}