{"id":117,"date":"2008-01-27T20:47:24","date_gmt":"2008-01-27T20:47:24","guid":{"rendered":"http:\/\/bodybuilding.ultimatefatburner.com\/?p=117"},"modified":"2015-02-16T13:37:09","modified_gmt":"2015-02-16T18:37:09","slug":"anabolic-pump-review","status":"publish","type":"post","link":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/anabolic-pump-review.html","title":{"rendered":"Review: USP Labs Anabolic Pump\/P-Slin"},"content":{"rendered":"<p><strong>Note: P-Slin is discontinued.<\/strong><\/p>\n<p>USP Labs&#8217; <strong>Anabolic Pump<\/strong> is advertised as a &#8220;Selective Insulin Muscle Sensitizer,&#8221; that &#8220;<em>&#8230;forces your body to naturally become super efficient in utilizing insulin only in muscle cells.<\/em>&#8221; <strong>P-Slin<\/strong> is billed as a &#8220;super-extracted version&#8221; of Anabolic Pump, so it seems appropriate to review both supplements together.<\/p>\n<p>So what are these supplements supposed to do?<\/p>\n<p>&#8220;<em>Anabolic-Pump\u2122 creates a phenomenon called &#8220;Super Nutrient Partitioning.&#8221; Super Nutrient Partitioning involves the creation of a metabolic environment in which nutrient energy is selectively retained in muscle tissue rather than fat&#8230;Anabolic-Pump\u2122 forces your body to naturally become super efficient in utilizing insulin only in muscle cells. The miraculous nature is that it completely shuts down the fat cell&#8217;s affinity to store glucose and triglycerides while causing lipolysis!<\/em>&#8221;<\/p>\n<blockquote><p>&#8220;P-Slin is specially designed to be used pre-workout when \u201cnutrient-flooding\u201d is most useful to the body to promote strength, size, definition, pumps, endurance and vascularity.&#8221;<\/p><\/blockquote>\n<p>In essence, USP Labs claims that Anabolic Pump and P-Slin will allow users to consume large amounts of carbohydrates, and ensure that they&#8217;re used for lean muscle growth, rather than fat gains. In fact, they state that users can actually lose body fat, while adding muscle.<\/p>\n<p>Does this sound like a dream come true, or what?<\/p>\n<p>But wait! Don&#8217;t reach for your wallet just yet. Let&#8217;s take a look at the ingredients and see how well they match up with the claims.<\/p>\n<blockquote><p><strong>Anabolic Pump<\/strong><br \/>\nServing Size 1 Capsule<br \/>\nServings Per Container90+<\/p>\n<p>Amount Per Serving<\/p>\n<p>AnabolicPump\u2122 750mg<br \/>\nP-Insulin\u2122 (Extract Engineered From Phellodendron HCL)<\/p>\n<p>Tannins Complex\u2122 (Extract Engineered From Lagerstroemia Speciosa)<\/p>\n<p>Symmetry\u2122 (Herbal Engineered Ketones From Cissus Quadrangularis)<\/p>\n<p><strong>P-Slin<\/strong><br \/>\nServing Size 1 Capsule<br \/>\nServings Per Container30<\/p>\n<p>Amount Per Serving<\/p>\n<p>Pure Blend 500mg<br \/>\nTannins Complex\u2122(Extract Engineered From Lagerstroemia Speciosa)<\/p>\n<p>Gymnemic Complex(Herbal Engineered From Gymnema Sylvestre)<\/p><\/blockquote>\n<p>Anabolic Pump contains only 3 ingredients: <em>Phellodendron<\/em> HCl extract, <em>Lagerstroemia speciosa<\/em> extract, and &#8220;herbal engineered ketones&#8221; from <em>Cissus quadrangularis<\/em>. P-Slin has 2 ingredients: <em>Lagerstroemia speciosa<\/em> extract (same as Anabolic Pump), and <em>Gymnema sylvestre<\/em> extract. It&#8217;s not a long list, so let&#8217;s see what each one has to offer.<\/p>\n<p><em>Phellodendron amurense<\/em> is otherwise known as &#8220;Amur Cork Tree.&#8221; A native of Asia, the bark has been used in Chinese traditional medicine to treat gastrointestinal problems, ulcers, diabetes and infections.<\/p>\n<p>Berberine is the best characterized of the compounds that have been identified. Berberine has antibacterial, anti-tumor and antioxidant activities. It may also have anti-diabetic activity: <a href=\"http:\/\/diabetes.diabetesjournals.org\/content\/55\/8\/2256.full.pdf+html\" target=\"_blank\" rel=\"noopener\">in one study, it decreased body fat and fasting glucose levels in rats<\/a>. This work is not conclusive, however, as the berberine was administered by injection, not consumed orally. Unfortunately, we don&#8217;t have many other in-vivo studies on berberine or <em>Phellodendron<\/em>.<\/p>\n<p>The only study on humans I could find in Western, peer-reviewed literature is on <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16454147?ordinalpos=25&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\"><em>Phelldendron<\/em> extract combined with <em>Magnolia officinalis<\/em><\/a>. This combination, currently sold as Relora, reduced weight gain in obese subjects by decreasing cortisol and stress-related eating. Thus, <em>Phellodendron<\/em> is promising, but much more research remains to be done.<\/p>\n<p><em>Lagerstroemia speciosa<\/em> is Banaba\u2014a tree native to Southeast Asia. The leaves have been used in traditional medicine in the Phillipines as a treatment for diabetes. As it turns out, the leaves are high in corosolic acid, which has been shown to improve glucose control <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12787964?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">in human<\/a> <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/27\/7\/27_7_1103\/_pdf\" target=\"_blank\" rel=\"noopener\">and animal<\/a> studies. It appears to do this by <a href=\"http:\/\/jn.nutrition.org\/content\/131\/9\/2242.full\" target=\"_blank\" rel=\"noopener\">stimulating glucose uptake<\/a> in muscle cells. Glucose transport is mediated by specific transporter proteins. Corosolic acid acts by <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/27\/7\/27_7_1103\/_pdf\" target=\"_blank\" rel=\"noopener\">increasing the amount of a particular transporter (GLUT-4) on the cell membrane surface<\/a>. Although more work remains to be done, banaba looks like a useful ingredient for treating hyperglycemia and diabetes.<\/p>\n<p><em>Cissus quadrangularis<\/em> is also known as &#8220;Veld Grape.&#8221; It&#8217;s another medicinal plant native to Africa, India, and other parts of Asia. <em>Cissus<\/em> has traditionally been used to treat a variety of ailments such as bone fractures, ulcers, wounds, indigestion and asthma. Animal studies have shown <em>Cissus<\/em> extracts may have <a href=\"http:\/\/www.icmr.nic.in\/ijmr\/2006\/june\/0614.pdf\" target=\"_blank\" rel=\"noopener\">gastroprotective effects<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14611887?ordinalpos=14&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">contribute to bone health<\/a>, and have <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12935320?ordinalpos=15&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">antioxidant\/antimicrobial activities<\/a>. A number of people swear by <em>Cissus<\/em> as an analgesic and use it to treat weight lifting injuries.<\/p>\n<p>Lately, <em>Cissus<\/em> has also been touted as a fat loss agent, thanks to two studies.<\/p>\n<p>The first was discussed <a href=\"https:\/\/www.ultimatefatburner.com\/cylaris-review.html\">by Paul in his review of Cylaris<\/a>. Of course, <a href=\"http:\/\/www.lipidworld.com\/content\/5\/1\/24\" target=\"_blank\" rel=\"noopener\">this study<\/a> actually tested the entire Cylaris formula\u2014which makes it difficult to draw conclusions about <em>Cissus<\/em> itself.<\/p>\n<p><a href=\"http:\/\/www.lipidworld.com\/content\/6\/1\/4\" target=\"_blank\" rel=\"noopener\">A second study<\/a>, however, did test a proprietary Cissus extract (CQR-300) and concluded it &#8220;<em>&#8230;brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors.<\/em>&#8221;<\/p>\n<p>So is <em>Cissus<\/em> effective for reducing blood glucose and enhancing fat loss? Personally, I&#8217;m somewhat skeptical.<\/p>\n<p>I&#8217;ve seen plenty of user reviews of bulk <em>Cissus<\/em> extracts for pain\/injury relief, yet have never seen any that mentioned fat loss as an effect. I&#8217;ve used it myself as well, and noticed no changes in body composition. My doubts have not been assuaged by these studies, either.<\/p>\n<p>Although they concern two different commercial formulations, both were performed by the same lead researcher: Julius Oben. And as it just so happens, <a href=\"http:\/\/patft.uspto.gov:80\/netacgi\/nph-Parser?Sect1=PTO1&amp;Sect2=HITOFF&amp;d=PALL&amp;p=1&amp;u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&amp;r=1&amp;f=G&amp;l=50&amp;s1=7,175,859.PN.&amp;OS=PN\/7,175,859&amp;RS=PN\/7,175,859\" target=\"_blank\" rel=\"noopener\">Dr. Oben has a patent on the use of <em>Cissus quadrangularis<\/em> as a fat loss agent<\/a>. This is an apparent conflict of interest, and I would prefer to see some confirmation from an independent laboratory before recommending <em>Cissus<\/em> for fat loss or glycemic control.<\/p>\n<p><em>Gymnema sylvestre<\/em> is native to India, and its leaves are a traditional folk medicine for diabetes. Several studies in <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2259217?ordinalpos=87&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">humans<\/a> and animals have confirmed it can improve glucose control, possibly by<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jvms\/59\/4\/59_4_245\/_pdf\" target=\"_blank\" rel=\"noopener\"> inhibiting glucose uptake in the small intestine<\/a> and <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11249615?ordinalpos=41&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">enhancing insulin release<\/a>. It may even have <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16691318?ordinalpos=9&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener\">positive effects on lipid metabolism<\/a> and has potential for use in <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2170951\/?tool=pubmed\" target=\"_blank\" rel=\"noopener\">treating diabetes and obesity<\/a>.<\/p>\n<p>Of the three ingredients in Anabolic Pump, the evidence is strongest for banaba. This ingredient is also included in P-Slin, along with <em>Gymnema<\/em>\u2014another promising extract. Thus, there is some decent evidence that these two supplements can, in fact, assist with glycemic control, although the extent is not known. USP Labs claims that &#8220;clinical studies&#8221; have been done, and provides several graphs on their web site. From the descriptions, however, these appear to be from cell culture (in-vitro) studies, so they don&#8217;t tell us much about how Anabolic Pump or P-Slin work in humans when taken as directed.<\/p>\n<p>I gave these two supplements a try myself. After checking out the diet directions on the USP Labs forum, I stocked up on brown rice, sweet potatoes, oatmeal, and a few other complex carb sources, along with waxy maize starch for pre- and post-workout. I made sure to get a minimum of 50 g complex carbs in the three meals I took Anabolic Pump with, and consumed a solid 75 g of carbs pre-workout, as recommended for P-Slin. This is fairly carb-intense for me, as I prefer to get most of my carbs from veggies, fruits and some dairy products, with only small amounts of starchy carbs (mostly from oatmeal).<\/p>\n<p>First, the good news: my workouts were pretty good\u2014not sensational\u2014but good. The pump from P-Slin was comparable to some NO supps I&#8217;ve taken. Now, the bad news: I gave it up after a week, as I found myself wanting to lay down and take a little nap 5\u20136 times a day. It didn&#8217;t feel like I was suffering from any hypoglycemic response\u2014as long as I was moving around, I was fine. But I couldn&#8217;t sit for more than 30\u201340 minutes without losing focus: my eyelids would start to droop and my head would sag towards the keyboard. Since I write for a living, this was no good. All the extra carbs were doing me in, so the experiment came to an abrupt end.<\/p>\n<p>Others have fared better: although there are some dissenters, the overall trend of the reviews I&#8217;ve seen have been positive. Naturally, very few of these report results as dramatic as the ones featured on the USP web site, which claim that testers gained an average of 7.3 lbs. of muscle and lost 5.4 lbs. in the first 14 days. Many users, however, seem to be satisfied with their purchases.<\/p>\n<p>Anabolic Pump and P-Slin certainly represent an interesting innovation: they aren&#8217;t your typical bodybuilding supplements. While I feel that the results may be somewhat exaggerated, these supplements could conceivably help curb fat gains on a bulking cycle. As such they could be worth experimenting with. Hopefully, they&#8217;ll work better for you than they did for me. \ud83d\ude09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Note: P-Slin is discontinued. USP Labs&#8217; Anabolic Pump is advertised as a &#8220;Selective Insulin Muscle Sensitizer,&#8221; that &#8220;&#8230;forces your body to naturally become super efficient in utilizing insulin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[18,19],"_links":{"self":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/117"}],"collection":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/comments?post=117"}],"version-history":[{"count":4,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/117\/revisions"}],"predecessor-version":[{"id":2566,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/posts\/117\/revisions\/2566"}],"wp:attachment":[{"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/media?parent=117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/categories?post=117"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ultimatefatburner.com\/bodybuilding\/wp-json\/wp\/v2\/tags?post=117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}