7-Keto-DHEA is an acetylated form of a DHEA metabolite (7-oxo-DHEA) used in a number of weight loss supplements. Unlike DHEA, it cannot be converted to androgens (i.e., testosterone) or estrogens.
Several studies in humans indicate that 7-Keto-DHEA can modestly increase RMR and enhance weight/fat loss when taken in conjunction with a structured diet and exercise program. Studies in rats have shown 7-keto may work by increasing levels of thermogenic enzymes. It may also help reduce cortisol (stress hormone) levels.
Also known as 3-acetyl-7-keto-DHEA and 3-acetyl-7-oxo-dehydroepiandosterone.